Serine/threonine-protein kinase 40 (IPR024236)

Short name: Ser/Thr_kinase_40

Overlapping homologous superfamilies

Family relationships


This entry represents serine/threonine-protein kinase 40 (STK40), also known as SINK-homologous inhibitory kinase (SHIK), which acts as a negative regulator of NF-kappa-B and p53-mediated gene transcription [PMID: 13679039]. It It was identified as a protein related to SINK, a p65-interacting protein that inhibits p65 phosphorylation by the catalytic subunit of PKA, thereby inhibiting transcriptional competence of NF-kappaB.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.