Cytochrome P450, cholesterol 7-alpha-monooxygenase-type (IPR024204)

Short name: Cyt_P450_CYP7A1-type

Overlapping homologous superfamilies

Family relationships


This group represents cytochrome P450, CYP7A1 type. Gene cyp7a1 codes for the enzyme cholesterol 7-alpha-monooxygenase, which catalyses a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. This enzyme is important for cholesterol homeostasis [PMID: 8088795]. Some of the enzymes belonging to this group are 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, also involved in bile acid biosynthesis, and prostacyclin synthase, which catalyses the isomerization of prostaglandin H2 to prostacyclin (prostaglandin I2).

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.