Fosfomycin resistance kinase, FomA-type (IPR024192)

Short name: Fosfomycin_R_FomA-type

Overlapping homologous superfamilies

Family relationships



This entry represents a group of isopentenyl phosphate kinases (IPKs). They catalyze the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids [PMID: 19928876]. This entry also includes FomA protein from Streptomyces.

Fosfomycin (L-(cis)-1,2-epoxy propyl phosphonic acid) is an antibiotic produced by some species of Streptomyces and Pseudomonas. As an analogue of phosphoenolpyruvate (PEP), this compound irreversibly inhibits PEP UDP-N-acetylglucosamine-3-O-enolpyruvyltransferase (enolpyruvyltransferase), which catalyses the first step of peptidoglycan biosynthesis [PMID: 10681332]. FomA is one of the fosfomycin resistance kinases. Together with FomB (encoded in the fosfomycin biosynthetic gene cluster of Streptomyces wedmorensis), FomA confer fosfomycin resistance on Escherichia coli [PMID: 10681332]. FomA catalyses phosphorylation of fosfomycin to fosfomycin monophosphate, and FomB phosphorylation of fosfomycin monophosphate to fosfomycin diphosphate, in the presence of ATP and a magnesium ion [PMID: 10681332]. Surprisingly, while FomA homologues are present in many organisms, including fosfomycin-producing ones, no homologues of FomB are detected to date.

FomA and related sequences are members of the Amino Acid Kinase Superfamily (AAK).

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016301 kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.