Adaptor protein Cbl (IPR024162)

Short name: Adaptor_Cbl

Overlapping homologous superfamilies


Family relationships



Cbl (Casitas B-lineage lymphoma) is an adaptor protein that functions as a negative regulator of many signalling pathways that start from receptors at the cell surface, including tyrosine kinases, cytokine receptors, and T-cell or B-cell receptors. There are three Cbl related proteins known to date: Cbl, CblB, and CblC/Cbl3 [PMID: 9824625]. Cbls function as ubiquitin E3 ligase proteins, accepting ubiquitin from specific E2 ubiquitin-conjugating enzymes and transferring it to substrates, promoting their degradation [PMID: 9653117] or endocytosis [PMID: 10393178].

GO terms

Biological Process

GO:0023051 regulation of signaling

Molecular Function

GO:0004842 ubiquitin-protein transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.