Family

Ragulator complex protein LAMTOR5 (IPR024135)

Short name: LAMTOR5

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Hepatitis B X-interacting protein (HBXIP, also known as LAMTOR5) was originally recognised for its association with the X protein of hepatitis B virus (HBV) and ability to down-regulate HBV replication [PMID: 9499022]. When complexed to the anti-apoptotic protein survivin, HBXIP interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerised APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway [PMID: 12773388]. HBXIP is one of the Ragulator components that are required for mTORC1 activation by amino acids [PMID: 22980980]. It is also part of the AA (amino acid) sensing machinery in human CD4+ T cells [PMID: 26084023].

GO terms

Biological Process

GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0019079 viral genome replication

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0071986 Ragulator complex
GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
PRINTS
Pfam