Transcription factor DEAF-1 (IPR024119)

Short name: TF_DEAF-1

Overlapping homologous superfamilies


Family relationships



Deformed epidermal autoregulatory factor-1 (DEAF-1) was first isolated in Drosophila melanogaster as a novel DNA-binding protein [PMID: 8617243]. Since then, several orthologues in mammals have been identified. In Drosophila, DEAF-1 plays an important role in embryonic development, particularly in the segmentation stage following cuticle secretion. In mammals it regulates different processes, including epithelial cell proliferation and side-branching in the mammary gland [PMID: 18826651] and it is required for neural tube closure and skeletal patterning [PMID: 14966286].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.