Pseudokinase tribbles, TRB3 (IPR024106)

Short name: Tribbles_TRB3

Overlapping homologous superfamilies

Family relationships


Tribbles encode an evolutionarily conserved protein family that influences proliferation, motility, metabolism, and oncogenic transformation. Originally identified in Drosophila, tribbles homologues are characterised by a central serine/threonine kinase-like domain (KD) and a C-terminal binding site for E3 ubiquitin ligases. Although the KD is the defining feature of the tribbles family, these proteins are considered to be catalytically inactive because they lack conserved residues from the characteristic adenosine triphosphate binding site and catalytic core motif within the KD [PMID: 20410507].

TRB-1, TRB-2 and TRB-3 are the mammalian homologues of Drosophila tribbles. This entry represents TRB-3, which binds to ATF4 and inhibits its transcriptional activation activity [PMID: 15781252]. It also interacts with and regulates activation of MAP kinases [PMID: 15299019].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003714 transcription corepressor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.