Tribbles homologue 1 (IPR024105)

Short name: TRB1

Overlapping homologous superfamilies

Family relationships


Tribbles encode an evolutionarily conserved protein family that influences proliferation, motility, metabolism, and oncogenic transformation. Originally identified in Drosophila, tribbles homologues are characterised by a central serine/threonine kinase-like domain (KD) and a C-terminal binding site for E3 ubiquitin ligases. Although the KD is the defining feature of the tribbles family, these proteins are considered to be catalytically inactive because they lack conserved residues from the characteristic adenosine triphosphate binding site and catalytic core motif within the KD [PMID: 20410507].

TRB-1, TRB-2 and TRB-3 are the mammalian homologues of Drosophila tribbles. This entry represents TRB-1, which interacts with and regulates activation of MAP kinases. It may not display kinase activity [PMID: 15299019].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.