Transcription factor EC (IPR024101)

Short name: TFEC

Overlapping homologous superfamilies


Family relationships


The MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors includes MITF (microphthalmia-associated transcription factor) and related family members TFE3, TFEB and TFEC [PMID: 7958932]. The transcription factors heterodimerize with each other and recognise the same DNA sequences [PMID: 15507434]. They recognise and bind E-box sequences (3'-CANNTG-5').

This entry represents transcription factor EC (TFEC). TFEC can act as a repressor or an activator. It acts as a transcriptional repressor on minimal promoter containing muE3 enhancer sequence [PMID: 8336698] and as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter [PMID: 11818452]. It binds DNA in a homo or heterodimeric form with MITF and TFE3.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0046983 protein dimerization activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.