Pathways & interactions
Transcription factor EC (IPR024101)
Short name: TFEC
Overlapping homologous superfamilies
- Basic helix-loop-helix leucine zipper transcription factor (IPR024097)
- Transcription factor EC (IPR024101)
The MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors includes MITF (microphthalmia-associated transcription factor) and related family members TFE3, TFEB and TFEC [PMID: 7958932]. The transcription factors heterodimerize with each other and recognise the same DNA sequences [PMID: 15507434]. They recognise and bind E-box sequences (3'-CANNTG-5').
This entry represents transcription factor EC (TFEC). TFEC can act as a repressor or an activator. It acts as a transcriptional repressor on minimal promoter containing muE3 enhancer sequence [PMID: 8336698] and as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter [PMID: 11818452]. It binds DNA in a homo or heterodimeric form with MITF and TFE3.
- PTHR12565:SF106 (PTHR12565:SF106)