Transcription factor E3 (IPR024100)

Short name: TFE3

Overlapping homologous superfamilies


Family relationships


The MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors includes MITF (microphthalmia-associated transcription factor) and related family members TFE3, TFEB and TFEC [PMID: 7958932]. The transcription factors heterodimerize with each other and recognise the same DNA sequences [PMID: 15507434]. They recognise and bind E-box sequences (3'-CANNTG-5').

This entry represents the transcription factor E3 (TFE3). In association with TFEB, TFE3 activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. It also has also a role in osteoclast development [PMID: 11930005]. TFE3 specifically recognises the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer [PMID: 16936731]. For efficient DNA-binding, TFE3 requires dimerisation with itself or with another MiT/TFE family member, such as TFEB or MITF.

GO terms

Biological Process

GO:0006959 humoral immune response
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045670 regulation of osteoclast differentiation

Molecular Function

GO:0046983 protein dimerization activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.