Pathways & interactions
Transcription factor E3 (IPR024100)
Short name: TFE3
Overlapping homologous superfamilies
- Basic helix-loop-helix leucine zipper transcription factor (IPR024097)
- Transcription factor E3 (IPR024100)
The MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors includes MITF (microphthalmia-associated transcription factor) and related family members TFE3, TFEB and TFEC [PMID: 7958932]. The transcription factors heterodimerize with each other and recognise the same DNA sequences [PMID: 15507434]. They recognise and bind E-box sequences (3'-CANNTG-5').
This entry represents the transcription factor E3 (TFE3). In association with TFEB, TFE3 activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. It also has also a role in osteoclast development [PMID: 11930005]. TFE3 specifically recognises the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer [PMID: 16936731]. For efficient DNA-binding, TFE3 requires dimerisation with itself or with another MiT/TFE family member, such as TFEB or MITF.
- PTHR12565:SF163 (PTHR12565:SF163)