Transcription factor EB (IPR024098)

Short name: TFEB

Overlapping homologous superfamilies


Family relationships



The MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors includes MITF (microphthalmia-associated transcription factor) and related family members TFE3, TFEB and TFEC [PMID: 7958932]. The transcription factors heterodimerize with each other and recognise the same DNA sequences [PMID: 15507434]. They recognise and bind E-box sequences (3'-CANNTG-5').

In association with TFE3, TFEB activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity [PMID: 16936731]. It also plays a role in the signal transduction processes required for normal vascularisation of the placenta [PMID: 9806910].

GO terms

Biological Process

GO:0006959 humoral immune response
GO:0045893 positive regulation of transcription, DNA-templated

Molecular Function

GO:0046983 protein dimerization activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.