Domain

Creatininase-like domain (IPR024087)

Short name: Creatininase-like_dom

Domain relationships

None.

Description

Creatinase (EC:3.5.2.10) catalyses the hydrolysis of creatinine to creatine, which can then be metabolised to urea and sarcosine by creatinase. Formamide hydrolase catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy) (EC:3.5.1.102).

Creatininase from Pseudomonas putida has a structure consisting of 3-layers, alpha/beta/alpha, where the core consists of a parallel beta-sheet of 4 strands. The enzyme is a typical Zn2+ enzyme with a binuclear metal centre [PMID: 15003455].

This entry represents the structural domain found in creatininases and in formamide hydrolases.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
SUPERFAMILY