Domain

Dihydrofolate reductase-like domain (IPR024072)

Short name: DHFR-like_dom

Domain relationships

Description

Dihydrofolate reductase (DHFR) catalyses the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, an essential step in de novo synthesis both of glycine and of purines and deoxythymidine phosphate (the precursors of DNA synthesis) [PMID: 2830673], and important also in the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate.

This entry represents a structural domain found in dihydrofolate reductases, as well as in riboflavin biosynthesis proteins (usually as a C-terminal domain) and related enzymes.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
SUPERFAMILY