Domain

Nucleoplasmin core domain (IPR024057)

Short name: Nucleoplasmin_core_dom

Overlapping homologous superfamilies

Domain relationships

None.

Description

This entry represents the core structural domain for the nucleoplasmin (Np) family of histone chaperone proteins. This core domain is formed by an 8-stranded beta barrel [PMID: 15576029].

The three branches of the Np family, including nucleophosmin (NO38/B23), nucleoplasmin (Np), and nucleoplasmin-like proteins (NLP), bind core histones and assemble nucleosomes in vitro assays. Even though they have different histone preferences, it has been suggested that Np family members may share a general mechanism for binding histones [PMID: 15576029].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam