Conserved Site

Formate/nitrite transporter, conserved site (IPR024002)

Short name: For/NO2_transpt_CS

Description

A number of bacterial and archaebacterial proteins involved in transporting formate or nitrite have been shown to be related [PMID: 8022272]

  • FocA and FocB, from Escherichia coli, transporters involved in the bidirectional transport of formate.
  • FdhC, from Methanobacterium formicicum and Methanothermobacter thermautotrophicus (Methanobacterium thermoformicicum), a probable formate transporter.
  • NirC, from E. coli and Salmonella typhimurium, a probable nitrite transporter.
  • Bacillus subtilis hypothetical protein YrhG.
  • B. subtilis hypothetical protein YwcJ (ipa-48R).

The 70 kd yeast hypothetical protein YHL008c is highly similar, in its N-terminal section, to the prokaryotic members of this family.

These transporters are proteins of about 280 residues and seem to contain six transmembrane regions. This entry represents two conserved sites, the first one located in what seems to be a cytoplasmic loop between the second and third transmembrane domains; the second one is part of the fourth transmembrane region.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns