Acireductone dioxygenase ARD, bacteria (IPR023956)

Short name: ARD_bac

Overlapping homologous superfamilies

Family relationships


Acireductone dioxygenase catalyses 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene), depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD or ARD') produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate,carbon monoxide and formate, and does not lie on the methionine recycle pathway [PMID: 8407993].

GO terms

Biological Process

GO:0019284 L-methionine salvage from S-adenosylmethionine
GO:0055114 oxidation-reduction process

Molecular Function

GO:0010308 acireductone dioxygenase (Ni2+-requiring) activity
GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity
GO:0005506 iron ion binding
GO:0016151 nickel cation binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.