D-tagatose-bisphosphate aldolase, class II, subunit GatY (IPR023955)

Short name: TagBP_aldolase_GatY

Overlapping homologous superfamilies

Family relationships



Escherichia coli and other enteric bacteria contain two closely related D-tagatose 1,6-bisphosphate (TagBP)-specific aldolases - KbaYZ (also known as AgaYZ) and GatYZ. Unlike other class II aldolases, which are homodimeric enzymes, KbaYZ and GatYZ are heterodimers, and are comprised of subunits KbaY/GatY and GatY/GatZ.

The KbaY/GatY subunits alone are sufficient to show aldolase activity and contain most or all of the residues that have been identified as essential for substrate/product recognition and catalysis in class II aldolases [PMID: 11976750, PMID: 8955298]. However, subunits GatZ/KbaZ are required for full activity and for good in vivo and in vitro stability.

This entry represents the GatY catalytic subunit of the GatYZ tagatose-1,6-bisphosphate aldolase. GatYZ is responsible for catalyzing the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP) [PMID: 8955298].

GO terms

Biological Process

GO:2001059 D-tagatose 6-phosphate catabolic process
GO:0019404 galactitol catabolic process

Molecular Function

GO:0009025 tagatose-bisphosphate aldolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.