Endo-type membrane-bound lytic murein transglycosylase A (IPR023946)

Short name: EmtA

Overlapping homologous superfamilies

Family relationships



This murein-degrading enzyme may play a role in the recycling of muropeptides during cell elongation and/or cell division. It catalsyses the endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue [PMID: 9642199]. Enzymatic cleavage activity occurs preferentially at a distance of more than two disaccharide units from the ends of the glycan chain. The enzyme is also called peptidoglycan lytic endotransglycosylase and belongs to the transglycosylase slt family.

GO terms

Biological Process

GO:0016998 cell wall macromolecule catabolic process

Molecular Function

GO:0016837 carbon-oxygen lyase activity, acting on polysaccharides
GO:0008932 lytic endotransglycosylase activity

Cellular Component

GO:0009279 cell outer membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.