Enolase-phosphatase E1 (IPR023943)

Short name: Enolase-ppase_E1

Overlapping homologous superfamilies

Family relationships


This enzyme is the enolase-phosphatase of methionine salvage, a pathway that regenerates methionine from methylthioadenosine (MTA). Adenosylmethionine (AdoMet) is a donor of different moieties for various processes, including methylation reactions. Use of AdoMet for spermidine biosynthesis, which leads to polyamine biosynthesis, leaves MTA as a by-product that must be cleared. In Bacillus subtilis and related species, this single protein is replaced by separate enzymes with enolase and phosphatase activities.

This entry also matches a number of probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 enzymes.

GO terms

Biological Process

GO:0019509 L-methionine salvage from methylthioadenosine

Molecular Function

GO:0043874 acireductone synthase activity
GO:0000287 magnesium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.