UDP-GlcNAc diphosphorylase/GlcNAc-1-P N-acetyltransferase, GlmU, bacterial-type (IPR023917)

Short name: Bifunctiontional_GlmU_bac-type

Overlapping homologous superfamilies

Family relationships



The MJ_1101 protein from Methanococcus jannaschii has been characterised as the GlmU, a bifunctional enzyme (UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase) catalyzing the final two steps of UDP-GlcNAc biosynthesis [PMID: 18263721]. Homologues of this enzyme are identified in a number of bacterial organisms. A number of these are observed in proximity to the glmS and glmM genes, and phylogenetic profiling [PMID: 16930487] identifies the LEPBI_I0518 gene in Leptospira biflexa as a likely Glm-system candidate. There are significant structural differences between these bacterial homologues with their archaeal counterparts represented by TIGR03992.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.