Conserved Site

Aliphatic acid kinase, short-chain, conserved site (IPR023865)

Short name: Aliphatic_acid_kinase_CS


Acetate kinase, which is predominantly found in micro-organisms, facilitates the production of acetyl-CoA by phosphorylating acetate in the presence of ATP and a divalent cation [PMID: 8226682, PMID: 8396545]. The enzyme is important in the process of glycolysis, enzyme levels being increased in the presence of excess glucose. The growth of a bacterial mutant lacking acetate kinase has been shown to be inhibited by glucose, suggesting that the enzyme is involved in excretion of excess carbohydrate [PMID: 8226682]. A related enzyme, butyrate kinase, facilitates the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate [PMID: 8396545].

This entry contains two signature patterns for these enzymes; the first one is located in the N-terminal section and the second in the central section. Both of them are glycine-rich and could be involved in substrate or ATP-binding.

GO terms

Biological Process

GO:0008152 metabolic process
GO:0016310 phosphorylation

Molecular Function

GO:0016301 kinase activity
GO:0016774 phosphotransferase activity, carboxyl group as acceptor

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns