Family

DNA integrity scanning protein, DisA (IPR023763)

Short name: DNA_integrity_scanning_protein

Overlapping homologous superfamilies

Family relationships

None.

Description

DNA integrity scanning protein (DisA) participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, disA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation [PMID: 9141693, PMID: 16713562].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP