2,3-diketo-L-gulonate reductase (IPR023689)

Short name: Diketo_gul_Rdtase

Overlapping homologous superfamilies

Family relationships


This entry represents a family of bacterial 2,3-diketo-L-gulonate reductases, which catalyse the reduction of 2,3-diketo-L-gulonate in the presence of NADH [PMID: 11741871]. The gene operon yiaK-S (of which yiaK encodes for the 2,3-diketo-L-gulonate reductase) is believed to encode proteins which are involved in the utilisation of rare sugars for growth. This enzyme relies on NAD-tartrate binding to produce a more open active site; the conformation of the free enzyme is incompatible with substrate binding [PMID: 14718529].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0047559 3-dehydro-L-gulonate 2-dehydrogenase activity
GO:0070403 NAD+ binding
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.