Pathways & interactions
Purine ribonucleoside efflux pump, NepI (IPR023680)
Short name: MFS_NepI
Overlapping homologous superfamilies
- MFS transporter superfamily (IPR036259)
- Major facilitator superfamily (IPR011701)
- Purine ribonucleoside efflux pump, NepI (IPR023680)
Among the different families of transporter, only two occur ubiquitously in all classifications of organisms. These are the ATP-Binding Cassette (ABC) superfamily and the Major Facilitator Superfamily (MFS). The MFS transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients [PMID: 9529885, PMID: 9868370].
This entry represents the nucleoside efflux permease-inosine (NepI) subfamily of the MSF superfamily. These proteins are nucleoside efflux pumps and are involved in the efflux of purine ribonucleosides, such as guanosine, adenosine and especially inosine [PMID: 16040204, PMID: 20814730].
- MF_01189 (MFS_NepI)