Purine ribonucleoside efflux pump, NepI (IPR023680)

Short name: MFS_NepI

Overlapping homologous superfamilies

Family relationships


Among the different families of transporter, only two occur ubiquitously in all classifications of organisms. These are the ATP-Binding Cassette (ABC) superfamily and the Major Facilitator Superfamily (MFS). The MFS transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients [PMID: 9529885, PMID: 9868370].

This entry represents the nucleoside efflux permease-inosine (NepI) subfamily of the MSF superfamily. These proteins are nucleoside efflux pumps and are involved in the efflux of purine ribonucleosides, such as guanosine, adenosine and especially inosine [PMID: 16040204, PMID: 20814730].

GO terms

Biological Process

GO:0015860 purine nucleoside transmembrane transport

Molecular Function

GO:0015211 purine nucleoside transmembrane transporter activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.