Transcription regulator HTH, PurR (IPR023588)

Short name: Tscrpt_reg_HTH_PurR

Overlapping homologous superfamilies

Family relationships



Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family groups together a range of proteins, including ascG, ccpA, cytR, ebgR, fruR, galR, galS, lacI, malI, opnR, purF, rafR, rbtR and scrR [PMID: 1639817, PMID: 1805309]. Within this family, the HTH motif is situated towards the N terminus.

This entry represents the bacterial helix-turn-helix transcriptional repressor PurR family. The purR gene encodes a transcriptional repressor of the HTH-type which is responsible for controlling the syntehsis of enzymed involved in purine biosynthesis [PMID: 2404765]. PurR is dimeric and consists of an N-terminal domain for DNA binding and a C-terminal domain which is responsible for corepressor (hypoxanthine and guanine) binding. Dimerisation sites are present in the C-terminal domain and binding of corepressors is cooperative [PMID: 1400170].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.