Family

Transcription regulator HTH, PurR (IPR023588)

Short name: Tscrpt_reg_HTH_PurR

Family relationships

None.

Description

Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family groups together a range of proteins, including ascG, ccpA, cytR, ebgR, fruR, galR, galS, lacI, malI, opnR, purF, rafR, rbtR and scrR [PMID: 1639817, PMID: 1805309]. Within this family, the HTH motif is situated towards the N terminus.

This entry represents the bacterial helix-turn-helix transcriptional repressor PurR family. The purR gene encodes a transcriptional repressor of the HTH-type which is responsible for controlling the syntehsis of enzymed involved in purine biosynthesis [PMID: 2404765]. PurR is dimeric and consists of an N-terminal domain for DNA binding and a C-terminal domain which is responsible for corepressor (hypoxanthine and guanine) binding. Dimerisation sites are present in the C-terminal domain and binding of corepressors is cooperative [PMID: 1400170].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP