CYTH-like domain (IPR023577)

Short name: CYTH-like_domain

Domain relationships


The CYTH domain is an ancient enzymatic domain that was present in the Last Universal Common Ancestor and was involved in nucleotide or organic phosphate metabolism [PMID: 12456267]. It is found in a variety of enzymes, including thiamine-triphosphatase and the CyaB-like adenlyl cyclases [PMID: 12456267]. Structurally, this domain consists mainly of antiparallel beta sheets that form a wide barrel with a channel running through it.

This entry represents the CYTH domain and a related structural domain found in the beta subunit of mRNA capping enzymes.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.