Peptidyl-prolyl cis-trans isomerase, FKBP-type (IPR023566)

Short name: PPIase_FKBP

Overlapping homologous superfamilies


Family relationships


FK506-binding proteins (FKBPs) are a particular class of peptidyl-prolyl cis-trans isomerases (PPIases) (EC: These proteins are found in a variety of organisms [PMID: 15353370]. In vertebrates, they are receptors for the two immunosuppressants FK506 and rapamycin. The drugs inhibit T cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. Peptidylprolyl isomerases accelerate protein folding by catalysing the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides. In Saccharomyces cerevisiae, FKBPs locate in nucleolus and interact with NOP53, which is a novel nucleolar 60S ribosomal subunit biogenesis protein [PMID: 15686447].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.