Methylated-DNA--protein-cysteine methyltransferase (IPR023546)

Short name: MGMT

Overlapping homologous superfamilies

Family relationships



The repair of DNA containing O6-alkylated guanine is carried out by DNA-[protein]-cysteine S-methyltransferase (EC:, also known as 6-O-methylguanine-DNA methyltransferase. The major mutagenic and carcinogenic effect of methylating agents in DNA is the formation of O6-alkylguanine. The alkyl group at the O-6 position is transferred to a cysteine residue in the enzyme [PMID: 3052269]. This is a suicide reaction since the enzyme is irreversibly inactivated and the methylated protein accumulates as a dead-end product [PMID: 3100503].

GO terms

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0003824 catalytic activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.