Threonylcarbamoyl-AMP synthase (IPR023535)

Short name: TC-AMP_synthase

Overlapping homologous superfamilies

Family relationships



This entry represents the threonylcarbamoyl-AMP synthase, includding RimN or YrdC (also known as TsaC) [PMID: 22378793], which is involved in the biosynthesis of N6-threonyl-carbamoyl-adenosine (t6A) modified tRNA. This is a universal modification, found at position 37 of ANN decoding tRNAs. Analysis shows that YrdC binds ATP and preferentially binds tRNA-Thr lacking the t6A modification [PMID: 19287007]. Furthermore YrdC has been shown to have threonine-dependent ATPase activity that generates AMP [PMID: 22378793]. YrdC (TsaC) and proteins YgjD (TsaD), YjeE (TsaE), and YeaZ (TsaB), are necessary and sufficient for t6A biosynthesis in vitro, and may constitute a complex.

GO terms

Biological Process

GO:0002949 tRNA threonylcarbamoyladenosine modification

Molecular Function

GO:0005524 ATP binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.