Homologous Superfamily

D-aminoacyl-tRNA deacylase-like superfamily (IPR023509)

Short name: DTD-like_sf

Overlapping entries

Description

This superfamily represents a D-aminoacyl-tRNA deacylase (DTD) fold, consisting of a beta-barrel closed on one side by a beta-sheet lid [PMID: 11568181]. The DTD fold is present across the domains of life in two different functional contexts: as an N-terminal editing domain of archaeal ThrRS (Threonyl-tRNA synthetase), which specifically removes noncognate L-serine mischarged on tRNAThr, and as a freestanding 'chiral proofreading' enzyme, which removes D-amino acids from tRNAs in bacteria and eukaryotes [PMID: 26113036].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY
GENE3D