Methionine-tRNA ligase, type 1 (IPR023458)

Short name: Met-tRNA_ligase_1

Overlapping homologous superfamilies

Family relationships


Methionine-tRNA ligase (EC: is an alpha 2 dimer. In some species (archaea, eubacteria and eukaryotes) a coding sequence, similar to the C-terminal end of MetRS, is present as an independent gene which is a tRNA binding domain as a dimer. In eubacteria, MetRS can also be split in two sub-classes corresponding to the presence of one or two CXXC domains specific to zinc binding. The crystal structures of a number of methionine-tRNA ligases are known [PMID: 10673435, PMID: 2254937, PMID: 10600385].

This entry represents type 1 methionine-tRNA ligase, found in eubacteria, archaea and eukaryotes.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004825 methionine-tRNA ligase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.