Flap endonuclease 1 (IPR023426)

Short name: Flap_endonuc

Overlapping homologous superfamilies

Family relationships


This entry represents an endonuclease that cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment [PMID: 9852084]. It has 5'-endo-/exonuclease and 5'-pseudo-Y-endonuclease activities and cleaves the junction between single and double-stranded regions of flap DNA.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016788 hydrolase activity, acting on ester bonds

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.