Domain

Axin interactor, dorsalization-associated protein, N-terminal (IPR023421)

Short name: AIDA_N

Domain relationships

None.

Description

This entry represents the N-terminal domain of the axin interactor, dorsalization-associated protein family AIDA [PMID: 17681137]. AIDA acts as a ventralizing factor during embryogenesis. It inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by axin/JNK-signaling [PMID: 17681137].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SUPERFAMILY
GENE3D