Homologous Superfamily

Radical SAM, alpha/beta horseshoe (IPR023404)

Short name: rSAM_horseshoe

Description

Radical SAM domains catalyze diverse reactions, including unusual methylations, isomerization, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation. Evidence exists that these proteins generate a radical species by reductive cleavage of S:-adenosylmethionine (SAM) through an unusual Fe-S centre [PMID: 11222759, PMID: 15317939].

This entry represents radical SAM domains that form an alpha/beta horseshoe structure [PMID: 20007320].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D