Domain

Translation Initiation factor eIF- 4e-like domain (IPR023398)

Short name: TIF_eIF4e-like_dom

Domain relationships

None.

Description

Eukaryotic translation initiation factor 4E (eIF-4E) [PMID: 1733496] is a protein that binds to the cap structure of eukaryotic cellular mRNAs. eIF-4E recognises and binds the 7-methylguanosine-containing (m7Gppp) cap during an early step in the initiation of protein synthesis and facilitates ribosome binding to a mRNA by inducing the unwinding of its secondary structures. A tryptophan in the central part of the sequence of human eIF-4E seems to be implicated in cap-binding [PMID: 1672854].

This entry represents an eIF4E-like domain, consisting of a curved eight-stranded antiparallel beta-sheet, decorated with three helices on the convex face and three smaller helices inserted in connecting loops [PMID: 9302999].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY
GENE3D