Domain

Mitochondrial carrier domain (IPR023395)

Short name: Mt_carrier_dom

Domain relationships

None.

Description

This entry represents a structural domain found in mitochondrial carrier proteins. Six alpha-helices form a compact transmembrane domain, which, at the surface towards the space between inner and outer mitochondrial membranes, reveals a deep depression. The structure suggests that transport substrates bind to the bottom of the cavity and that translocation results from a transition from a 'pit' to a 'channel' conformation [PMID: 14603310].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
SUPERFAMILY