Domain

BART domain (IPR023379)

Short name: BART_dom

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This domain is found in ADP-ribosylation factor-like 2 (ARF2) binding protein, also known as BART. BART binds specifically to ARF2.GTP with a high affinity. However, it does not bind to ARF2.GDP. It is thought that this specific interaction is due to BART being the first identified ARF2-specific effector. The function is not completely characterised [PMID: 10488091]. BART is predominantly cytosolic but can also be found to be associated with mitochondria. BART is also involved in binding to the adenine nucleotide transporter ANT1 [PMID: 11809823].

The interactions between ARL2 and BART involve a conserved N-terminal LLxIL motif of ARL2 [PMID: 19368893]. This domain is also found in CFAP36/CCDC104, a protein renamed as BARTL1. The BART-like domain of CCDC104/BARTL1 recognizes an LLxILxxL motif at the N-terminal amphipathic helix of ARL3 [PMID: 26455799].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam