Homologous Superfamily

Membrane associated eicosanoid/glutathione metabolism-like domain superfamily (IPR023352)

Short name: MAPEG-like_dom_sf

Overlapping entries


This domain is found in a widespread superfamily known as MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) [PMID: 10091672]. Included in this superfamily are:

  • 5-lipoxygenase activating protein (gene FLAP), which seems to be required for the activation of 5-lipoxygenase.
  • Leukotriene C4 synthase (EC:, which catalyses the production of LTC4 from LTA4.
  • Microsomal glutathione S-transferase II (EC: (GST-II), which also produces LTC4 from LTA4.
  • Prostaglandin E synthase, which catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid).

The structure of this domain consists of four transmembrane helices [PMID: 17600184].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.