Homologous Superfamily

Penicillin amidase type, domain 1 (IPR023343)

Short name: Penicillin_amidase_dom1

Overlapping entries


Penicillin amidase or penicillin acylase catalyses the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins [PMID: 9292993].

This superfamily represents the N-terminal structural domain of the penicillin amidase peptidases. It forms an alpha-helical orthogonal bundle [PMID: 11601852]. This domain is also found in other S45 peptidases like Glutaryl-7-aminocephalosporanic-acid acylase.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.