Arterivirus NSP4 peptidase domain (IPR023338)

Short name: Arterivirus_NSP4_peptidase

Overlapping homologous superfamilies

Domain relationships



Arteriviruses are enveloped, positive-stranded RNA viruses and include pathogens of major economic concern to the swine- and horse-breeding industries:

  • Equine arteritis virus (EAV).
  • Porcine reproductive and respiratory syndrome virus (PRRSV).
  • Mice actate dehydrogenase-elevating virus.
  • Simian hemorrhagic fever virus.

The arterivirus replicase gene encodes two large precursor polyproteins that are processed by the viral main proteinase nonstructural protein 4 (NSP4). The structure of the enzyme reveals two chymotrypsin-like antiparallel beta- barrels and an extra C-terminal alpha/beta domain that may play a role in mediating protein-protein interactions. The N-terminal barrel consists of six beta-strands (A1 to F1), while the C-terminal barrel is composed of seven (A2 to G2). The core of both beta-barrels is comprised of conserved hydrophobic residues. The additional C-terminal domain consists of two pairs of short antiparallel beta-sheets and two alpha-helices. It interacts with the C-terminal barrel through an interface consisting of conserved hydrophobic residues. A canonical catalytic triad that is composed of Ser, His, and Asp is located in the open cleft between the beta-barrels domain [PMID: 12163505, PMID: 19646449]. The nsp4 proteinase domain is a member of peptidase family S32.

The is entry represents the NSP4 proteinase domain.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008233 peptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles