Domain

c-Kit-binding domain (IPR023337)

Short name: KBD

Domain relationships

None.

Description

This entry represents the c-Kit binding domain found in metazoan Spread (Sprouty-related, EVH1 domain-containing) proteins. This domain has been shown to be necessary for Spread-1 phosphorylation and is not similar to other previously reported tyrosine kinase interacting domains, such as SH2 or c-Met binding domains [PMID: 11493923].

Despite being matched by this signature, Spread-3 family members contain inactive c-Kit binding domains as an arginine residue essential for c-Kit binding is mutated to glycine [PMID: 12646235].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles