Domain

REKLES domain (IPR023334)

Short name: REKLES_domain

Domain relationships

None.

Description

This entry represents the REKLES domain, found at the C-terminal of Bright/Dril1/ARID3a proteins. These proteins are B cell-specific, matrix association (or attachment) region-binding transcriptional regulator of immunoglobulin heavy chain genes and of E2F1-dependent cell cycle progression. The REKLES domain is essential for nuclear import and Crm1-dependent nuclear export of Bright [PMID: 16507996]. This domain is also involved in Bright multimerisation, which is necessary for DNA binding [PMID: 17400556]. The REKLES domain may be further subdivided into an N-terminal alpha and C-terminal beta subdomains.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles