Homologous Superfamily

Methuselah ectodomain, domain 2 (IPR023311)

Short name: Methusela_ecto_dom_2

Overlapping entries


Drosophila Methuselah (Mth) mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage. The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family. Mth, like secretin receptor family members, has a large N-terminal ectodomain, which may constitute the ligand binding site [PMID: 11274391].

This entry represents a structural subdomain found at the C-termimus of the Methusela ectodomain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.