Homologous Superfamily

Ammonia/methane monooxygenase, subunitB, N-terminal (IPR023301)

Short name: NH3_CH4_mOase_suB_N

Overlapping entries


Ammonia monooxygenase and the particulate methane monooxygenase are both integral membrane proteins, occurring in ammonia oxidisers and methanotrophs respectively, which are thought to be evolutionarily related [PMID: 7590173]. These enzymes have a relatively wide substrate specificity and can catalyse the oxidation of a range of substrates including ammonia, methane, halogenated hydrocarbons and aromatic molecules [PMID: 12209257]. These enzymes are composed of 3 subunits - A (IPR037001), B (IPR023301, IPR023303) and C (IPR023349) - and contain various metal centres, including copper. Particulate methane monooxygenase from Methylococcus capsulatus str. Bath is an ABC homotrimer, which contains mononuclear and dinuclear copper metal centres, and a third metal centre containing a metal ion whose identity in vivo is not certain[PMID: 15674245].

The soluble regions of these enzymes derive primarily from the B subunit. This subunit forms two antiparallel beta-barrel-like structures and contains the mono- and di- nuclear copper metal centres [PMID: 15674245].

This entry represents the N-terminal beta-barrel-like domain of subunit B.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.