Aquaporin 11 (IPR023266)

Short name: Aquaporin_11

Overlapping homologous superfamilies

Family relationships


The aquaporins (AQPs) are a family of integral membrane proteins composed of two subfamilies: the orthodox aquaporins, which transport only water, and the aquaglyceroporins, which transport glycerol, urea, or other small solutes [PMID: 16650285]. AQP1 in pleural mesothelial cells participate in the formation of pleural fluid [PMID: 18067818], renal AQP2 is involved in levels of solutes [PMID: 18419953] and changes in AQP9 in the hippocampus are related to delayed neuronal death [PMID: 17526024]. Aquaporins contain two tandem repeats, each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Aquaporin-11 (AQP11) and aquaporin-12 belong to a new aquaporin subfamily termed superaquaporins [PMID: 19096782]. AQP11 is found in the endoplasmic reticulum and has been connected to policystic kidney disease through knock-out experiments [PMID: 18606867]. It has also been shown that although the characteristic NPA motif may not be fully conserved in both tandem repeats, the molecule nevertheless preserves its water-transport function [PMID: 17178102].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.