Activity-regulated cytoskeleton-associated protein (IPR023263)

Short name: Activity-reg_cytoskelet-assoc

Overlapping homologous superfamilies


Family relationships



Arc (Activity-Regulated Cytoskeleton-associated protein), also referred to as arg3.1 (Activity-Regulated Gene), is a mammalian immediate-early gene that has been implicated in synaptic plasticity, and learning and memory processes [PMID: 17088213, PMID: 17088211, PMID: 17088212, PMID: 15908132]. It has been shown that Arc/Arg3.1 expression increases with strong synaptic activation [PMID: 17088212]. Its mRNA is transported to activated dendritic regions, conferring on the protein-distribution temporal correlation with the inducing stimulus and spatial specificity [PMID: 17088212].

Via interactions with dynamin and endophilin isoforms, the Arc/Arg3.1 protein enhances receptor endocytosis [PMID: 17088211]. Specifically, it modulates trafficking of neuronal AMPA-type glutamate receptors (AMPARs) by accelerating endocytosis and reducing surface expression [PMID: 17088211]. In particular, Arc/Arg3.1 has been shown to reduce the number of GluR2/3 receptors, leading to a decrease in AMPAR-mediated synaptic currents [PMID: 17088212]. These observations are consistent with a role in homeostatic regulation of synaptic strength [PMID: 17088212].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.