Family

Autophagy-related protein 14 (IPR023261)

Short name: Autophagy-related_protein_14

Family relationships

Description

Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells [PMID: 11689437]. In yeast, 15 autophagy (Apg) proteins coordinate the formation of autophagosomes. Apg14p and Vps30p/Apg6p, components of an autophagy-specific phosphatidylinositol 3-kinase complex, together with Apg9p and Apg16p, are required for localisation of Apg5p and Aut7p to a pre-autophagosome structure that functions in autophageosome formation [PMID: 11689437, PMID: 11157979]. Mutations in the Saccharomyces cerevisiae APG14 gene have been shown to cause defects in autophagy [PMID: 9712845].

GO terms

Biological Process

GO:0016236 macroautophagy

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS
ProDom
  • PD871282 (Autophagy-related_protein_14)