Family

Aurora borealis protein (IPR023252)

Short name: Aurora_borealis_protein

Family relationships

None.

Description

Aurora-A, a protein kinase required for centrosome maturation, spindle assembly and asymmetric protein localisation during mitosis, is activated by Aurora borealis protein at the onset of the mitotic cycle [PMID: 16890155]. Bora is a nuclear protein in interphase cells, but is excluded from the nucleus and translocates to the cytoplasm in a Cdc2-dependent manner when the cell enters mitosis [PMID: 16890155]. It has been suggested that activation of Cdc2 initiates the release of Bora into the cytoplasm, where it binds and activates Aurora-A [PMID: 16890155].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
PRINTS
Pfam