Cyclin-dependent kinase 2-interacting protein (IPR023250)

Short name: Cyclin-dep_Kinase_2_interact

Overlapping homologous superfamilies


Family relationships



Cyclin-dependent kinase 2-interacting protein (CINP) is a component of the active cyclin E/Cdk2 and cyclin A/Cdk2 complexes [PMID: 16082200]. It is phopshorylated by Cdc7, but not by Cdk2 [PMID: 16082200]. CINP has also been shown to bind to chromatin in a replication-dependent manner, and to associate with Origin Recognition Complex-2 (ORC2)-containing complexes and minichromosome maintenance/DNA replication licensing complex, MCM [PMID: 16082200]. It has been proposed that CINP is part of the Cdc7-dependent mechanism of origin firing, and constitutes a physical link between Cdk2 and Cdc7 complexes at the origins [PMID: 16082200].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.