FAM175 family (IPR023238)

Short name: FAM175

Overlapping homologous superfamilies


Family relationships


Members of protein family FAM175 include the BRCA1-A complex subunit Abraxas 1 [PMID: 17525340, PMID: 18077395], BRISC complex subunit Abraxas 2 or Abro1 (Abraxas brother protein 1) [PMID: 19214193, PMID: 19261749], and uncharacterised plant proteins.

It is thought that BRCA1-A complex subunit Abraxas acts as a central scaffold protein responsible for assembling the various components of the BRCA1-A complex, and mediates recruitment of BRCA1 [PMID: 17525340, PMID: 18077395]. Similarly, Abro1 probably acts as a scaffold facilitating assembly of the various components of BRISC [PMID: 19214193] - the protein does not interact with BRCA1, but binds polyubiquitin [PMID: 19261749]. The primary sequences of these proteins contain an MPN-like domain [PMID: 19261749].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.